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Peptides  >  Antimicrobial and Related Peptides  >>  Histatin-8 [Hemagglutination-Inhibiting Peptide (HIP)]

Product Name Histatin - 8 [Hemagglutination - Inhibiting Peptide (HIP)]
KFHEKHHSHRGY
Size 1 mg
Catalog # AS-61002
US$ $99
Purity % Peak Area By HPLC ≥ 95%
Description

Human salivary histatins (Hsts), which belong to a salivary polypeptide family, are small, cationic, histidine-rich proteins. They have potent bactericidal and antifungal activities against Candida albicans and Cryptococcus neoformans, and are therefore potential therapeutic reagents against Candida species.They kill fungal cells by binding to the cell membrane, internalizing, and disrupting volume regulatory mechanisms and mitochondrial function, leading to the production of reactive oxygen species and non-lytic loss.

Storage -20C
References Yoshida, M. et al. Biol. Pharm. Bull. 24, 1267 (2001); Ahmad, M. et. al. J. Histochem. Cytochem. 52, 361 (2004).
Molecular Weight 1562.7
Sequence
(One-Letter Code)
KFHEKHHSHRGY
Sequence
(Three-Letter Code)
H - Lys - Phe - His - Glu - Lys - His - His - Ser - His - Arg - Gly - Tyr - OH
Product Citations Walters, S.M. et al. (2010). Antibiotic-induced Porphyromonas gingivalis LPS release and inhibition of LPS-stimulated cytokines by antimicrobial peptides. Peptides doi:10.1016/j.peptides.2010.06.001.
     
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