Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Cell Permeable Peptides (CPP) / Drug Delivery Peptides  >>  NGR Peptide 3

Product Name NGR Peptide 3
CNGRC - NH2 (Disulfide bridge: 1 - 5)
Size 1 mg
Catalog # AS-60191-1
US$ $121
Description

This is a cyclic pentapeptide with NGR (Asn-Gly-Arg) motif and has been identified as an aminopeptidase N (APN) /CD13 in the endothelium. When conjugated with Doxorubicin, this peptide shows prodrug properties with antiproliferative and anti-angiogenic effects.

Detailed Information Datasheet
Storage -20C
References 1, Colombo, G. et al. J. Biol. Chem. 277, 47891 (2002)
2, Van Hensbergen, Y. et al. Biochem. Pharmacol. 63, 897 (2002).
Molecular Weight 548.6
Sequence
(One-Letter Code)
CNGRC-NH2 (Disulfide bridge: 1-5)
Sequence
(Three-Letter Code)
H - Cys - Asn - Gly - Arg - Cys - NH2 (Disulfide bridge: 1 - 5)
Product Citations Ma, X. et al. (2011). Gas-phase fragmentation of [M+ nH+OH]n●+ ions formed from peptides containing intra-molecular disulfide bonds. J Am Soc Mass Spectrom22, 922-930. doi: 10.1007/s13361-011-0104-1.

Plesniak, L. et al. (2010). Structure and activity of CPNGRC: A modified CD13/APN peptidic homing motif. Chem Biol Drug Des75, 551. doi: 10.1111/j.1747-0285.2010.00974.x.

Mintz, P. et al. (2002). Fingerprinting the circulating repertoire of antibodies from cancer patients. Nature Biotechnol21, 57. doi: 10.1038/nbt774.
     
  < Back