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Peptides  >  FRET Peptides  >>  Beta-Secretase Substrate 1a

Product Name Beta - Secretase Substrate 1a
Mca - EVKVDAEF - K(Dnp)
Size 1 mg
Catalog # AS-60268
US$ $253
Purity % Peak Area By HPLC ≥ 95%
Description

▀-Secretase (BACE1) is a key enzyme involved in the production of A▀ peptides found in extracellular amyloid plaques of Alzheimerĺs disease (AD). The enzyme has been implicated as an excellent target for anti-amyloid therapy of AD. This FRET peptide is an internally quenched fluorescent substrate based on the ▀-Secretase-cleavable peptide sequence. Upon cleavage by ▀-Secretase, the Mca fragment is liberated from the proximity quenching effect of Dnp (2,4-dinitrophenyl), Abs/Em=325/393 nm.

Storage -20░C
Molecular Weight 1447.5
Sequence
(One-Letter Code)
Mca-EVKVDAEF-K(Dnp)
Sequence
(Three-Letter Code)
Mca - Glu - Val - Lys - Val - Asp - Ala - Glu - Phe - Lys(Dnp) - OH
Product Citations Zhang, QG. et al. (2013). Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. Brain 136, 1432. doi: 10.1093/brain/awt046.
     
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