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Peptides  >  Antimicrobial and Related Peptides  >>  mCRAMP, mouse

Product Name mCRAMP, mouse
GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ
Size 1 mg
Catalog # AS-61305
US$ $275
Purity % Peak Area By HPLC ≥ 95%
Description

This cathelicidin-related antimicrobial peptide (mCRAMP) is the sole murine cathelicidin. mCRAMP expression in the intestinal tract is restricted to surface epithelial cells in the colon. mCRAMP shows antimicrobial activity against the murine enteric pathogen Citrobacter rodentium and destroys skin Candida albicans.

Detailed Information Datasheet
Storage -20C
References Limura, M. et al. J. Immunol. 174, 4901 (2005); Lopez-Garcia, B. et al. J. Invest. Dermatol. 125, 108 (2005).
Molecular Weight 3878.7
Sequence
(One-Letter Code)
GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ
Sequence
(Three-Letter Code)
H - Gly - Leu - Leu - Arg - Lys - Gly - Gly - Glu - Lys - Ile - Gly - Glu - Lys - Leu - Lys - Lys - Ile - Gly - Gln - Lys - Ile - Lys - Asn - Phe - Phe - Gln - Lys - Leu - Val - Pro - Gln - Pro - Glu - Gln - OH
Product Citations Sakoulas, G. et al. (2014). Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med 92, 139.
Subramanian, H. et al. (2013). β-Defensins activate human mast cells via Mas-Related Gene X2. J Immunol 191, 345. doi:10.4049/​jimmunol.1300023.
Kulkarni, MM. et al. (2011). Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection.Cell Microbiol 13, 913. doi: 10.1111/j.1462-5822.2011.01589.x.
Gregorio, J. et al. (2010). Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med 207, 2921.
Gable, JE. et al. (2009). Fluorescence and UV resonance Raman study of peptide−vVesicle interactions of human cCathelicidin LL-37 and its F6W and F17W mutants Biochem 48, 11264. doi: 10.1021/bi900996q.
Schlamadinger, DE. et al. (2009). Toxins and antimicrobial peptides: interactions with membranes.SPIE Proceedings 7397 doi: 10.1117/12.827439.
Gryllos, I. et al. (2008). Induction of group A Streptococcus virulence by a human antimicrobial peptide. PNAS 105, 16755.
     
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