This peptide, with amino acids 63 to 79, is a fragment of the myelin basic protein and is the dominant encephalitogenic peptide for DA rats. Rats develop experimental autoimmune encephalomyelitis (EAE) after the immunization with this peptide. This sequence was also used in the research attempts to prevent EAE with neutralizing antibodies to IFN-gamma-Inducing Factor.
Lenz, D. et al. J. Immunol. 163, 1763 (1999); Wildbaum, G. et al. J. Immunol. 161, 6368 (1998), Swanborg, R. Immunol. Rev 184, 129 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Thr - His - Tyr - Gly - Ser - Leu - Pro - Gln - Lys - Ser - Gln - Arg - Ser - Gln - OH