This short synthetic peptide facilitates efficient transdermal protein drug delivery through intact skin. Co-administration of the peptide and insulin to the abdominal skin of diabetic rats results in elevated systemic levels of insulin and suppresses serum glucose levels. This peptide creates a transient opening in the skin barrier to enable macromolecular drugs to reach systemic circulation.
Chen, Y. et al. Nat. Biotechnol.24, 455 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Cys - Ser - Ser - Ser - Pro - Ser - Lys - His - Cys - Gly - OH