This is an amino acids 79 to 87 fragment of the myelin basic protein (MBP). Injection of this peptide induces a high avidity T cell repertoire in shiverer mice that primarily consisted of clones capable of recognizing the native MBP protein, in addition to the peptide itself. Endogenous MBP is not required for the positive selection of an MBP-specific T cell repertoire. C3H mice, in contrast, are selectively unresponsive to the MBP protein and injection of this MBP peptide induces a low avidity repertoire that could be stimulated only by the peptide, not by the protein.
Targoni, O. and Lehmann, P. J. Exp. Med. 187, 2055 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Asp - Glu - Asn - Pro - Val - Val - His - Phe - Phe - OH