This is amino acids 101 to 120 fragment of myelin oligodendrocyte glycoprotein (MOG), one of the major MOG B-cell epitopes in transgenic mice. MOG is a potential target antigen of the central nervous system known to induce autoreactive T cell response and demyelinating anti-MOG antibodies in multiple sclerosis (MS) patients. Studies demonstrated that a quantitatively minor myelin protein, MOG, is also strongly encephalogenic in mice, rats, marmosets, and rhesus monkeys, which is highly relevant to MS.
Khare, M. et al. Int. Immunol. 15, 535 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Asp - His - Ser - Tyr - Gln - Glu - Glu - Ala - Ala - Met - Glu - Leu - Lys - Val - Glu - Asp - Pro - Phe - Tyr - OH