This peptide is amino acids 323 to 339 amidated fragment of ovalbumin (OVA), the H-2b-restricted OVA class II epitope. This peptide is recognized by many T cells because it contains multiple T cell epitopes. This OVA fragment contains a nested set of CD4+ T cell epitopes. OVA 323 to 339 can be presented by I-Ad in at least three binding registers. The residues 327 to 333 are critical for peptide binding to I-Ad
Robertson, J. et al. J. Immunol. 164, 4706 (2000), Oran, A. and Robinson, H. J. Immunol. 171, 1999 (2003), Nag, B. et al. J. Immunol. 148, 2040 (1992), Hongming, Z. et al. J. Bacteriol. 187, 175 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ile - Ser - Gln - Ala - Val - His - Ala - Ala - His - Ala - Glu - Ile - Asn - Glu - Ala - Gly - Arg - NH2