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Recombinant Proteins  >  HCV (Hepatitis C Virus)  >>  HCV NS3/4A protease genotype 1b, recombinant

Product Name HCV NS3/4A protease genotype 1b, recombinant
Size 5 µg
Catalog # 61017-5
US$ $247
Description

The NS3 protease of hepatitis C virus (HCV) is responsible for the cleavage at the NS3/NS4A, NS4A/NS4B, NS4B/NS5A, and NS5A/NS5B sites of the nonstructural protein. It is essential for viral replication and the formation of infectious viral particles, and thus has been considered as one of the most attractive targets for anti-HCV therapy. Recombinant HCV NS3/4A protease is highly active and can be used with SensoLyte® 490, 520, or 620 HCV Protease Assay Kits (Cat# 71126, 71145, 71146) to screen for anti-HCV protease drugs.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Poster
Product Citations Ma, C. et al. (2009). HCV Protease Inhibitory, Cytotoxic and Apoptosis-Inducing Effects of Oleanolic Acid Derivatives. J Pharm Pharmaceut Sci 12, 243.
"Phuong, DT. et al. (2009). Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease. Phytother Res 23, 582."
"Yu, X. (2009). Development of a cell-based hepatitis C virus (HCV) infection FRET assay for high throughput antiviral compound screening. Antimicrob Agents Chemo doi:10.1128/AAC.00495-09."
Ma, C. et al. (2007). Triterpenes from Cynomorium songaricium —analysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating. J Nat Med 63, 9.
     
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