KR-12 is the smallest active segment of LL-37, a peptide derived from the C-terminal domain of human cathelicidin antimicrobial peptide (CAMP). KR-12 exhibits antimicrobial activity specifically against gram-negative bacteria by inducing lateral-phase segregation within the bacterial membrane.
Berno, B. et al. Antimicrob Agents Chemother53, 3705 (2009).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Arg - Ile - Val - Gln - Arg - Ile - Lys - Asp - Phe - Leu - Arg - OH