This cationic antimicrobial peptide is Sub5, a variant of Bac2a containing five amino acid substitutions. Sub5 directly interacts with ATP to inhibit ATP-dependent enzymes, and shows activity against Gram-positive and Gram-negative bacteria, fungi, parasites, and viruses.
Hilpert, K. et al. Antimicrob Agents Chemother doi:10.1128/AAC.01664-09, (2010).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Arg - Trp - Lys - Ile - Val - Val - Ile - Arg - Trp - Arg - Arg - NH2