Peptides  >  Angiotensins and Related Peptides
The renin-angiotensin system plays an important role in regulating blood volume, arterial pressure, cardiac and vascular function, and may contribute to the pathogenesis of atherosclerosis. It stimulates an increase in nitric oxide synthase mRNA, protein expression, and nitric oxide production in pulmonary vessels. This system is found in various vertebrates, from elasmobranchs to mammals. Angiotensins consist of at least three polypeptide hormones: angiotensin I (Ang I), angiotensin II (Ang II), and angiotensin III (Ang III). Ang I is derived from a protein secreted by the liver by the action of renin, an enzyme that acts on a circulating substrate, angiotensinogen, which then undergoes proteolytic cleavage to form the decapeptide Ang I. Ang I is converted to Ang II by the angiotensin converting enzyme (ACE) or kininase II, a dipeptidyl-carboxypeptidase. Ang II is a potent pressor agent in the regulation of blood pressure, the conservation of total blood volume and salt homeostasis. It controls the release of antidiuretic hormone (ADH) and aldosterone. Ang II is the precursor of Ang III, which in turn stimulates aldosterone release from the adrenal glands.

Ref: Lévy, B. Circulation 109, 8 (2004); Olson, S. et al. Am. J. Physiol. Lung. Cell Mol. Physiol. 287, L559 (2004); Johnston, CI. Drugs 39, 21 (1990); Kranzhofer, R. et al. Biochem. Biophys. Res. Commun. 257, 826 (1999); Takei, Y. et al. Gen. Comp. Endocrinol. 110, 140 (1998); Cobb, C. et al. Gen. Comp. Endocrinol. 127, 8 (2002); Spyroulias, G. et al. Eur. J. Biochem. 270, 2163 (2003).
 Product Size Catalog # US$  
Angiotensin (1 - 5)
DRVYI
DRVYI
1 mg 61179 $66
Angiotensin (1 - 7)
DRVYIHP
DRVYIHP
1 mg 61039 $66
Angiotensin (1 - 9)
DRVYIHPFH
DRVYIHPFH
1 mg 61041 $83
Angiotensin I Converting Enzyme 2, (ACE - 2) Substrate
Mca - APK(Dnp)
Mca - APK(Dnp)
1 mg 60757 $132
Angiotensin I Converting Enzyme 2, ACE - 2/Caspase - 1 Substrate
Mca - YVADAPK(Dnp)
Mca - YVADAPK(Dnp)
1 mg 60758 $237
Angiotensin I, human
DRVYIHPFHL
DRVYIHPFHL
5 mg 20627 $25
Angiotensin I, human
DRVYIHPFHL
DRVYIHPFHL
25 mg 20628 $121
Angiotensin I/II (3 - 8)
VYIHPF
VYIHPF
5 mg 60701 $44
Angiotensin II Substrate
DRV - pY - IHPF
DRV - pY - IHPF
1 mg 24520 $237
Angiotensin II Substrate
DRV - pY - IHPF
DRV - pY - IHPF
5 mg 24521 $946
Angiotensin II, human
DRVYIHPF
DRVYIHPF
5 mg 20633 $33
Angiotensin II, human
DRVYIHPF
DRVYIHPF
25 mg 20634 $121
Angiotensin II, human, FAM - labeled
FAM - DRVYIHPF
FAM - DRVYIHPF
0.5 mg 60275-05 $105
Angiotensin II, human, FAM - labeled
FAM - DRVYIHPF
FAM - DRVYIHPF
1 mg 60275-1 $171
Angiotensin II, human, TAMRA - labeled
TAMRA - DRVYIHPF
TAMRA - DRVYIHPF
1 mg 61181 $181
Angiotensin III
RVYIHPF
RVYIHPF
5 mg 60704 $44
Apstatin, Aminopeptidase P Inhibitor
N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl] - PPA - NH2
N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl
] - PPA - NH2
1 mg 61832-1 $71
Apstatin, Aminopeptidase P Inhibitor
N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl] - PPA - NH2
N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl
] - PPA - NH2
5 mg 61832-5 $242
Apstatin, Aminopeptidase P Inhibitor
N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl] - PPA - NH2
N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl
] - PPA - NH2
25 mg 61832-25 $1111
Biotin - LC - Angiotensin II
Biotin - LC - DRVYIHPF
Biotin - LC - DRVYIHPF
1 mg 60276-1 $66
Biotin - LC - Angiotensin II
Biotin - LC - DRVYIHPF
Biotin - LC - DRVYIHPF
5 mg 60276-5 $264
ClearPoint Angiotensin I, human, 13C and 15N labeled
DR - V* - Y - I* - HPFHL [Val* = Val(U - 13C5,15N); Ile* = Ile(U - 13C6,15N)]
DR - V* - Y - I* - HPFHL [Val* = Val(U - 13C5,15N); Ile* = Ile(U - 13C6,15N)]
0.1 mg 65140 $77
ClearPoint Angiotensin II, human, 13C and 15N - labeled
DRVY - I* - HPF [I*= I(U13C6,15N)]
DRVY - I* - HPF [I*= I(U13C6,15N)]
0.1 mg 64805 $143
ClearPoint™ Angiotensin I, human, 13C and 15N - labeled
DRVY - I* - HPFHL [I*= I(U13C6,15N)]
DRVY - I* - HPFHL [I*= I(U13C6,15N)]
0.1 mg 61182 $143
DX 600, ACE2 Inhibitor
Ac - GDYSHCSPLRYYPWWKCTYPDPEGGG - NH2
Ac - GDYSHCSPLRYYPWWKCTYPDPEGGG - NH2
0.1 mg 62337 $121
HRP Prorenin, Decoy Handle Region (31 - 40), rat
RILLKKMPSV
RILLKKMPSV
1 mg 62118 $61
Peptide Substrate for Renin 520 Assay kit 0.1 mg 61872-01 $220
Peptide Substrate for Renin 520 Assay kit 1 mg 61872 $1320
Rat Renin FRET Substrate (5 - FAM/QX® 520) 0.1 mg 62334-01 $220
Rat Renin FRET Substrate (5 - FAM/QXL® 520) 1 mg 62334 $1320
Rat Renin Inhibitor Peptide, WFML Peptide
Ac - HPFV - (Sta) - LF - NH2
Ac - HPFV - (Sta) - LF - NH2
1 mg 60463-1 $181
Renin 390 FRET Substrate I
R - E(EDANS) - IHPFHLVIHT - K(DABCYL) - R
R - E(EDANS) - IHPFHLVIHT - K(DABCYL) - R
1 mg 62022 $215
Renin Inhibitor III
RRPFH - Sta - IHK
RRPFH - Sta - IHK
5 mg 72066 $775
Renin Substrate, human 1 mg 20631 $61
Renin Substrate, human
DRVYIHPFHLVIHN
DRVYIHPFHLVIHN
5 mg 20632 $193
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