Thrombospondin (TSP) is a glycoprotein with three identical disulfide-bonded subunits. It is a widely distributed extracellular matrix protein and has been identified as an active agent in angiogenesis, platelet aggregation and cell adhesion. It has been implicated in processes such as wound healing, tumor growth and metastasis. Thrombospondin is an inhibitor of the fibrinolytic enzyme, plasmin and acts as a competitive inhibitor of neutrophil elastase. It mediates adherence of CD36+ sickle reticulocytes to endothelial cells.
Ref: Sugihara, K. et al. Blood 80, 2634 (1992); Iruela-Arispe, N. et al. Int. J. Biochem. Cell Biol. Junb. 36, 1070 (2004); Sargiannidou, I. et al. Exp. Biol. Med. 226, 726 (2001); Hogg, P. et al. Biol. Chem. 268, 7139 (1993); Guo, N. et al. J. Biol. Chem. 267, 19349 (1992).