Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. MMP-8 (collagenase-2, neutrophil collagenase) is involved in quite a few diseases such as cancer, arthritis and asthma. The SensoLyteŽ 490 MMP-8 Assay Kit is a complete assay system designed to continuously analyze MMP activities or to screen MMP-8 inhibitors by using a fluorogenic MMP-8 substrate. The assays are performed in a convenient 96-well or 384-well microplate format. The kit provides speed, convenience and accuracy in analyzing MMP-8 activities and screening MMP-8 inhibitors.