Oxonol VI is used as an optical indicator for membrane potentials in lipid vesicles. Oxonol VI is a sensitive slow-response membrane potential probe whose magnitude of optical response is much larger than that of faster response probes (Oxonol V). The fluorescence of Oxonol VI decreases upon membrane hyperpolarization. In general, slow response probes are suitable for detecting changes in average membrane potentials of nonexcitable cells caused by respiratory activity, ion-channel permeability, drug binding and other factors.
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