Aßs are generated by the proteolytic processing of the amyloid ß-precursor protein (APP). Subsequent cleavage by g-secretase gives rise to Aß (1-40/42) and Aß (11-40/42). Aß (11-40) and Aß (11-42) are major Aß cleavage products generated by BACE.
Pyr - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - OH