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Peptides  >  Amyloid Peptides  >  Beta-Amyloid (1-42) and Related Peptides  >>  [Pyr11]-beta-Amyloid (11-42), Human
Product Name [Pyr11] - beta - Amyloid (11 - 42), Human
Pyr - VHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Size 1 mg
Catalog # AS-29903-1
US$ $484
Purity % Peak Area By HPLC ≥ 95%
Description

Aßs are generated by the proteolytic processing of the amyloid ß-precursor protein (APP). Subsequent cleavage by g-secretase gives rise to Aß (1-40/42) and Aß (11-40/42). Aß (11-40) and Aß (11-42) are major Aß cleavage products generated by BACE.
Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Liu, K. et al. Biochem. 41, 3128 (2002).
Molecular Weight 3317.9
Sequence
(One-Letter Code)		 Pyr-VHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence
(Three-Letter Code)		 Pyr - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - OH
Product Citations D'Arrigo, C. et al. (2009). N‐terminal truncated pyroglutamyl β amyloid peptide Aβpy3‐42 shows a faster aggregation kinetics than the full‐length Aβ1‐42. Biopolymers 91, 861. doi: 10.1002/bip.21271.

Feld, M. et al. (2008). Effect on memory of acute administration of naturally secreted fibrils and synthetic amyloid-beta peptides in an invertebrate model. Neurobiol Learn Mem 89, 407. doi: 10.1016/j.nlm.2007.08.011.

Piccini, A. et al. (2005). β-Amyloid is different in normal aging and in Alzheimer disease. J. Biol. Chem. 280, 34186. doi: 10.1074/jbc.M501694200.
     
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