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Peptides  >  Cell Permeable Peptides (CPP) / Drug Delivery Peptides  >>  NGR Peptide 3

Product Name NGR Peptide 3
CNGRC - NH2 (Disulfide bridge: 1 - 5)
Size 1 mg
Catalog # AS-60191-1
US$ $121

This is a cyclic pentapeptide with NGR (Asn-Gly-Arg) motif and has been identified as an aminopeptidase N (APN) /CD13 in the endothelium. When conjugated with Doxorubicin, this peptide shows prodrug properties with antiproliferative and anti-angiogenic effects.

Detailed Information Datasheet
Storage -20C
References 1, Colombo, G. et al. J. Biol. Chem. 277, 47891 (2002)
2, Van Hensbergen, Y. et al. Biochem. Pharmacol. 63, 897 (2002).
Molecular Weight 548.6
(One-Letter Code)
CNGRC-NH2 (Disulfide bridge: 1-5)
(Three-Letter Code)
H - Cys - Asn - Gly - Arg - Cys - NH2 (Disulfide bridge: 1 - 5)
Product Citations Ma, X. et al. (2011). Gas-phase fragmentation of [M+ nH+OH]n●+ ions formed from peptides containing intra-molecular disulfide bonds. J Am Soc Mass Spectrom22, 922-930. doi: 10.1007/s13361-011-0104-1.

Plesniak, L. et al. (2010). Structure and activity of CPNGRC: A modified CD13/APN peptidic homing motif. Chem Biol Drug Des75, 551. doi: 10.1111/j.1747-0285.2010.00974.x.

Mintz, P. et al. (2002). Fingerprinting the circulating repertoire of antibodies from cancer patients. Nature Biotechnol21, 57. doi: 10.1038/nbt774.
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