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Peptides > Endothelins >> Endothelin 1, human, porcine

Product Name	Endothelin 1, human, porcine CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1 - 15 and 3 - 11)
Size	0.25 mg
Catalog #	AS-22859
US$	$181
Purity	% Peak Area By HPLC ≥ 95%
Description	ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
Detailed Information	Datasheet Material Safety Data Sheets (MSDS)
Storage	-20°C
References	Ref: Yanagisawa, M. et al. Nature. 332, 411 (1988).
Molecular Weight	2492
Sequence (One-Letter Code)	CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11)
Sequence (Three-Letter Code)	H - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11)
Product Citations	Ansar, S. et al. (2009). Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. J Neurosurg 111, 5. Wang, Y. et al. Brain Res. 1167, 118 (2007). Cervar-Zivkovic, M. et al. Reprod. Sci. 14, 430 (2007). Beg, SAS. et al. J. Cer. Blood Flow Metab. 26, 846 (2006). Ansar, S. et al. J. Neurosurgery 106, DOI: 10.3171/jns.2007.106.5.881 (2006).

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