Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Stay Logged In

Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Angiotensins and Related Peptides  >>  Angiotensin II Substrate

Product Name Angiotensin II Substrate
Size 1 mg
Catalog # AS-24520
US$ $237
Purity % Peak Area By HPLC ≥ 95%

This is a tyrosine phosphorylated angiotensin II peptide with a substrate sequence specificity for chymase to act. This is an octapeptide hormone that is formed as a result of the action of human heart chymase, a chymotrypsin-like serine protease on the Phe-His bond of Angiotensin I. The ideal susbtrate for human heart chymase should contain this peptide sequence, and has been demonstrated that the Pro-Phe sequence in P2-P1 positions of peptide substrates is highly favored by leukocyte chymotrypsin-like proteinases such as chymases and cathepsin G.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References 1, Kinoshita A, et al. J Biol Chem 266(29): 19192-19197 (1991).
2, Ruzzene, M. et al. Eur. J. Biochem. 211, 289 (1993).
Molecular Weight 1126.2
(One-Letter Code)
(Three-Letter Code)
H - Asp - Arg - Val - pTyr - Ile - His - Pro - Phe - OH
Product Citations Crowe, MC. and Brodbelt, JS. (2004). Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociation of peptides in a quadrupole ion trap with selective IRMPD of phosphopeptides. J. Am. Soc. for Mass Spectrom 15, 1581. doi: 10.1016/j.jasms.2004.07.016.

Woods, A. S. et al. J. (2003). Angiotensin II–Acetylcholine noncovalent complexes analyzed with MALDI–Ion mobility–TOF MS. Biomol. Tech 14, 1.
  < Back