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Peptides  >  Cell Permeable Peptides (CPP) / Drug Delivery Peptides  >>  [Cys58]105Y, Cell Penetrating Peptide, α1-antitrypsin (358-374)

Product Name [Cys58]105Y, Cell Penetrating Peptide, α1 - antitrypsin (358 - 374)
Size 1 mg
Catalog # AS-62005
US$ $105

This is a synthetic peptide based on the sequence corresponding to residues 359 to 374 of α1-antitrypsin. C105Y can penetrate cell membrane rapidly, enter the cytoplasm, and localize to the nucleus and nucleolus of live culture cells. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion; whereas membrane translocation and nuclear localization are energy-independent. It enhances gene expression from DNA nanoparticles.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References M. Rhee and P. Davis J. Biol. Chem. 281, 1233 (2006).
Molecular Weight 1994.4
(One-Letter Code)
(Three-Letter Code)
H - Cys - Ser - Ile - Pro - Pro - Glu - Val - Lys - Phe - Asn - Lys - Pro - Phe - Val - Tyr - Leu - Ile - OH
Product Citations Bartz, R. et al. (2011). Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape. Biochem J doi:10.1042/BJ20101021.
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