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Amino Acids  >  Unusual Amino Acids  >  Azide and Alkyne containing Amino Acids  >>  Fmoc-L-propargylglycine

Product Name Fmoc - L - propargylglycine
CAS 198561-07-8
Size 1 g
Catalog # AS-26264-F1
US$ $181
Purity ≥95% by HPLC

An unusual amino acid used in Solid Phase Peptide Synthesis (SPPS) as: A) a precursor to the tritium-induced Norvaline peptides1, B) in the synthesis of branched peptides using a palladium-catalyzed coupling reaction2, and C) as a reagent in the dual-catalyst Sonogashira coupling reaction.3

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage 4C
References 1. Eberle, A. N.; Zeller, A. Tritiation of Peptides to High Specific Radioactivity. Part 1. Synthesis and Biological Properties of [13-(3H4)Norvaline]-α-MSH and of [2,23-Bis((3H2)tyrosine)]ACTH(1-24). Helvetica Chim. Acta. 1985 (68) 1880-1892.
2. Crisp, G. T.; Robertson, T. A. Palladium-catalyzed coupling of a propargylglycinededrivative. Tetrahedron. 1992 (48) 3239-3250.
3. Sonogashira, K.; Tohda, Y.; Haghiara, N. A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes, and bromopyridines.Tetrahedron Lett.,1975 (16) 4467-4470.
Molecular Weight 335.4
Molecular Formula C20H17NO4
Product Citations Grieshaber, SE. et al. (2009). Synthesis and characterization of elastin−mimetic hybrid polymers with multiblock, alternating molecular architecture and elastomeric properties. Macromolecules 42, 2532. doi: 10.1021/ma802791z.
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