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Recombinant Proteins  >  α-Synuclein & β-Synuclein  >>  Recombinant human α-Synuclein (1-140), HiLyte™ Fluor 488 labeled

Product Name Recombinant human α - Synuclein (1 - 140), HiLyte™ Fluor 488 labeled
Size 200 µg
Catalog # AS-55457
US$ $508.2
Purity Greater than 90% as determined by SDS-PAGE.
Description

The recombinant human a-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with the fluorescence dye HiLyte™ Fluor 488.

Parkinson's disease is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of a-synuclein is a critical step in the etiology of Parkinson's disease (PD). a-Synuclein is an abundant brain protein of 140 residues that is present in high concentrations at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested, and it appears to be involved in vesicle release and trafficking.

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Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage HiLyte FluorTM 488 labeled human a-synuclein is supplied frozen at 1 mg/ml in 10 mM sodium phosphate buffer (pH=7.0). Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for up to 12 months. Keep in dark and avoid repeated freeze-thaw cycles.
References 1.     Trojanowski, J. Q. & Lee, V. M. (2003) Ann. N. Y. Acad. Sci. 991, 107-110.
2.     Masliah, E., et al. (2000) Science 287, 1265-1269.
3.     Van Der, P. H, et al. (2000) J. Neurosci. 20, 6021-6029.
4.     Feany, M. B. & Bender, W. W. (2000) Nature 404, 394-398.
5.     Weinreb,  P. H., et al. (1996) Biochemistry35, 13709-13715.
Spectral Properties Green fluorescence. Excitation/Emission wavelengths= 490nm/525nm
     
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