Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Recombinant Proteins  >  α-Synuclein & β-Synuclein  >>  Recombinant Human β-Synuclein (1-134)

Product Name Recombinant Human β - Synuclein (1 - 134)
Size 0.1 mg
Catalog # AS-55458-100
US$ $125
Purity Greater than 90% as determined by SDS-PAGE.
Description

The sequence (Accession # NP_003076)) corresponding to the human β-synuclein along with a 6x His tag was expressed in E. coli.

Endotoxin (EU/μg): Less than 1 EU per 1 μg of the protein as determined by Limulus Amebocyte Lysate (LAL) quantitative kinetic assay.

Beta-synuclein belongs to the family of highly conservative proteins in vertebrates. N-terminal of β-synuclein is highly homologous to α-, γ-synucleins and consists of degenerative “KTKEGV” repeats (1-4). Similar to α-synuclein, beta-synuclein is found primarily in the brain; however, it does not associate with Lewy bodies in Parkinson disease like α-synuclein (1-4). Beta-synuclein was found to inhibit production of phosphatidic acid by the phospholipase D2 transmembrane protein in vitro (1). In addition, beta-synuclein was detected in many breast and ovarian tumors (4). Recent investigations demonstrated that beta-synuclein can induce mild experimental autoimmune encephalomyelitis (EAE) in Lewis rats (5).

Click link to learn more about AnaSpec's products for: Parkinson's & Alzheimer's Disease Research

Images Recombinant Human β-Synuclein (1-134)
Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage Purified human β-synuclein is supplied as sterile and frozen at 1 mg/ml in the following buffer: 20 mM Tris-HCl, 0.1 M NaCl, 1 mM MgCl2, pH 7.5. Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for up to 6 months. Avoid repeated freeze-thaw cycles.
References 1.     Rivers R.C. et. al. (2008) Protein Science 17: 887-898
2.     Sung Y.-H. et. al. (2006) Protein Science 15: 1162-1174
3.     George J. M. (2001) Genome Biology 3 (1): 3002.1-3002.6
4.     Bruening W. et. al. (2000) American Cancer Society 88 (9): 2154-216
5.     Kela-Madar N. et. al. (2009) Journal of Neuroimmunology 208: 19-29
Molecular Weight 18 kDa
     
  < Back