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Peptides  >  Cyclic Peptides  >  Cyclo (N →C) Peptides  >>  Cyclo (-RGDyK)

Product Name Cyclo ( - RGDyK)
Cyclo( - RGDyK)
Size 5 mg
Catalog # AS-61183-5
US$ $193
Purity % Peak Area By HPLC ≥ 95%

This is a cyclic derivative of RGD having a high affinity for αvβ3 integrin. It is considered the most prominent structure for the development of molecular imaging compounds in order to determine αvβ3 expression. It has been shown that both purified and membrane-bound αvβ3 intergrin binds to c(RGDyK) with high affinity.

Detailed Information Datasheet
Storage -20C
References 1, Huang, X-W. et al. Biochemical Pharmacology 80, 136143 (2010).
2, Chen, X. et al. Bioconjug. Chem. 15, 41 (2004).
Molecular Weight 619.7
(One-Letter Code)
(Three-Letter Code)
Cyclo( - Arg - Gly - Asp - D - Tyr - Lys)
Product Citations Guan, F. et al. (2011). Sequence elucidation of an unknown cyclic peptide of high doping potential by ETD and CID tandem mass spectrometry. J. Am. Soc. Mass Spectrom 22, 718. doi: 10.​1007/​s13361-011-0080-5.

Xiong, X. et al. (2010). The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin. Biomater 31, 757. doi: 10.1016/j.biomaterials.2009.09.080.

Zako, T. et al. (2009). Cyclic RGD peptide-labeled upconversion nanophosphors for tumor cell-targeted imaging. Biochem Biophys Res Commun 381, 54. doi: 10.1016/j.bbrc.2009.02.004.
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