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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ Beta-Amyloid 1-16 , Monoclonal Antibody, BiotinLabeled

Product Name OptimAbᵀᴹ Beta - Amyloid 1 - 16 , Monoclonal Antibody, BiotinLabeled
Clone: 6E10; Host: Mouse, Monoclonal Antibody
Size 100 µg/100 µl
Catalog # SIG-39340-100
US$ $422
Description

Beta-Amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Beta-Amyloid (1-42) is the principal species associated with senile plaque amyloids, while Beta-Amyloid (1-40) is more abundant in cerebrovascular amyloid deposits. Both result from the cleavage of Amyloid Precursor Protein (APP) by secretases. The mAb 6E10 reacts to the abnormally processed isoforms, as well as precursor forms.

Host:Mouse
Clone: 6E10
Isotype: IgG1
Reactivity: Human
Immunogen: This antibody is reactive to residues 1-16 of Beta-Amyloid. The epitope lies within amino acids 3-8 of the peptide (EFRHDS)
Concentration:1 mg/mL
Formulation:PBS (no preservatives); The Ab was purified on Protein G and biotin-labeled
Applications:The Ab is effective in immunoblotting (WB), immunohistochemistry (IHC), immunoprecipitation (IP) and ELISA.
Working Dilutions:WB: 1/1.000 - 1/2.000 (predicted MW: APP=~100kDa; beta-Amyloid = 4kDa)

Detailed Information Datasheet
Storage 4°C
References 1, Thakker DR et al. (2009) Proc. Natl. Acad. Sci. USA 106(11): 4501-4506.
2, Klyubin I, et al. (2005) Nat. Med. 11(5): 556-61.
3, Oddo S, et al. (2005) Proc. Natl. Acad. Sci; USA 102(8): 3046-51.
4, Funamoto S, et al. (2004) Biochem. 43: 13523-13540.
5, Herzig M, et al. (2004) Nat. Neuro. 7(9): 954-959.
     
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