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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ Beta-Amyloid 17-24 , Monoclonal Antibody, BiotinLabeled

Product Name OptimAbᵀᴹ Beta - Amyloid 17 - 24 , Monoclonal Antibody, BiotinLabeled
Clone: 4G8; Host: Mouse, Monoclonal Antibody
Size 100 µg/100 µl
Catalog # SIG-39240-100
US$ $422
Description

Beta-Amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Beta-Amyloid (1-42) is the principal species associated with senile plaque amyloids, while Beta-Amyloid (1-40) is more abundant in cerebrovascular amyloid deposits. Both result from the cleavage of Amyloid Precursor Protein (APP) by secretases. The mAb 4G8 reacts to the abnormally processed isoforms, as well as precursor forms.

Host:Mouse
Clone: 4G8
Isotype: IgG2b
Reactivity: Human, Mouse
Immunogen: This antibody is reactive to residues 17-24 of Beta-Amyloid. The epitope lies within amino acids 18-22 of Beta-Amyloid (VFFAE)
Concentration:1 mg/mL
Formulation:PBS (no preservatives); The Ab was purified on Protein G and biotin-labeled
Applications:The Ab is effective in immunoblotting (WB), immunohistochemistry (IHC), immunoprecipitation (IP) and ELISA.
Working Dilutions:WB: 1/100 - 1/1.000 (predicted MW: APP=~100kDa; beta-Amyloid = 4kDa)

Detailed Information Datasheet
Storage 4°C
References 1, Thakker DR et al. (2009) Proc. Natl. Acad. Sci. USA 106(11): 4501-4506.
2, Kimura N et al. (2005) Neuropath. Appl. Neurobiol. 31(2): 170-180.
3, Klyubin I et al. (2005) Nat. Med. 11(5): 556-561.
4, Iijima K et al. Proc. Natl. Acad. Ssi. USA (2004) 101(17): 6623-6628.
5, Li M et al. (2004) J. Neurochem. 91: 623-633.
     
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