Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ Beta-Amyloid 1-42 , Monoclonal Antibody, purified

Beta-Amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Beta-Amyloid (1-42) is the principal species associated with senile plaque amyloids, while Beta-Amyloid (1-40) is more abundant in cerebrovascular amyloid deposits. Both result from the cleavage of Amyloid Precursor Protein (APP) by secretases. The mAb 12F4 reacts with the C-terminus of Beta-Amyloid and is specific to the isoform ending at the 42nd residue.

Host:Mouse
Clone: 12F4
Isotype: IgG1
Reactivity: Human, Mouse
Immunogen: This antibody is reactive to the C-terminus of Beta-Amyloid and is specific for the isoform ending at the 42nd amino acid
Concentration:0.5 mg/mL
Formulation:PBS (no preservatives); The Ab is purified
Applications:The Ab is effective in immunoblotting (WB), immunohistochemistry (IHC) and ELISA.
Working Dilutions:WB: 1/100 - 1/1.000 (predicted MW: beta-Amyloid = 4kDa)