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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ Neuronal Class III beta-Tubulin Polyclonal Antibody, purified

Product Name OptimAbᵀᴹ Neuronal Class III beta - Tubulin Polyclonal Antibody, purified
Host: Rabbit, Polyclonal Antibody
Size 50 g/50 L
Catalog # PRB-435P-050
US$ $288
Description

This antibody was raised against microtubules derived from rat brain. It is highly reactive to neuron specific Class III -tubulin (III), but does not cross-react on -tubulin found in glial cells.
Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors and is used as a predictive and prognostic marker in various tumors.

Host:Rabbit
Clone: N/A
Isotype: N/A
Reactivity: Mammalian
Immunogen: This pAb was raised against microtubules derived from rat brain
Concentration:1 mg/mL
Formulation:PBS + 50% Glycerol + 0.03% Thimerosal. The Ab was purified by affinity chromatography
Applications:The Ab is effective in immunoblotting (WB) and immunostaining (IHC, ICC).
Working Dilutions:WB: 1/5.000 (predicted MW: 50 kDa)
ICC: 1/1.000 - 1/2.500
IHC: 1/5.000 - 1/10.000

Detailed Information Datasheet
Storage 4C
References 1, Feuer R et al. (2005) J. Neurosci. 25(9): 2434-44.
2, Mozzetti S et al. (2005) Clin. Cancer Res. 11(1): 298-305.
3, Feuer R et al. (2003) Am. J. Pathol. 163(4): 1379-93.
4, Zhang XM & Yang XJ (2001). Development 128(6): 943-957.
     
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