Beta-Amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Beta-Amyloid (1-42) is the principal species associated with senile plaque amyloids, while Beta-Amyloid (1-40) is more abundant in cerebrovascular amyloid deposits. Both result from the cleavage of Amyloid Precursor Protein (APP) by secretases. This rabbit anti-sAPPß pAb is specific for the soluble fragment of APP, cleaved N-terminus to the beta-secretase cleavage site. It has negligible cross reactivity to sAPP? or full length APP.
Host:RabbitClone: N/AIsotype: N/AReactivity: Human, RodentImmunogen: ndConcentration:1 mg/mLFormulation:PBS (no preservatives). The Ab is affinity purifiedApplications:The Ab is effective in immunoblotting (WB), immunohistochemistry (IHC) and ELISA.Working Dilutions:WB: 1/500 - 1/1.000 ELISA: 2.5 - 250 ng/mlStrage Instruction:Store at 4°C; do not store antibody diluted below 50µg/ml in the absence of carrier protein (e.g. add 2% BSA)