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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ LRRK2 , Monoclonal Antibody, purified

Product Name OptimAbᵀᴹ LRRK2 , Monoclonal Antibody, purified
Clone: MC.; Host: Mouse, Monoclonal Antibody
Size 50 g/50 L
Catalog # SIG-39840-050
US$ $83

(This product is not available for sale in Australia, France, Germany, Switzerland, and the United Kingdom due to IP restrictions.)

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2; augmented in rheumatoid arthritis 17) functions as a kinase and GTPase. Mutations of LRRK2 have been associated with an increased risk of Parkinson's disease and Crohn's disease.

Immunogen: This mAb was raised against a peptide immunogen comprising amino acids 2069-2087 of the LRRK2 protein in mice that did not express endogenous LRRK2 protein, in an effort to elicit greater antigenic reaction and higher affinity antibody

Clone: MC.
Isotype: IgG1
Reactivity: Human, Mouse, Rat, Dog, Primate
Concentration:1 mg/mL
Formulation:PBS; The Ab is purified
Applications:The Ab is effective in immunoblotting (WB), ELISA and immunohistochemistry (IHC).
Positive control tissue: human mid-brain or pancreas.
Working Dilutions:WB: 1/2.000 (predicted molecular weight: 250 kDa)
ELISA: 1/200
IHC: 1/50 - 1/100

Detailed Information Datasheet
Storage 4C
References 1, Paisan-Ruiz C et al. (2004) Neuron 44(4): 595-600.
2, Zimprich A et al. (2004) Neuron 44(4): 601-607.
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