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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ alpha-Synuclein , Monoclonal Antibody, purified

Product Name OptimAbᵀᴹ alpha - Synuclein , Monoclonal Antibody, purified
Clone: LB509 Host: Mouse, Monoclonal Antibody
Size 100 µg/100 µl
Catalog # SIG-39725-100
US$ $355

Descriptions:Alpha-Synuclein is a 140 amino acid protein that is implicated in Parkinson’s disease, Alzheimer’s disease, Lewy body dementia, and multiple system atrophy. It is mainly produced in the brain, but is also present at low levels in many other tissues. The protein contains 3 domains, a N-terminal amphipathic domain, a central hydrophobic domain which contains the NAC region (non-amyloid-beta component), involved in protein aggregation, and a C-terminal proline-rich domain. At least 3 isoforms of alpha-Synuclein are generated by alternative splicing, the most common form being the full length 1-140.
LB159 recognizes amino acids 115-122 of human alpha-Synuclein.

Clone: LB509
Isotype: IgG1
Reactivity: Human; does not react with Rodent alpha-Synuclein
Immunogen: The LB509 Ab recognizes aa 115-122 of human alpha-Synuclein
Concentration:1 mg/mL
Formulation:PBS (with no preservatives). The Ab is purified
Applications:The Ab is effective in immunoblotting (WB), ELISA and immunohistochemistry (IHC).
Working Dilutions:WB: 1/100 - 1/10.000 ; IHC: 1/100- 1/1000

Detailed Information Datasheet
Storage 4°C
References 1, Iwatsubo T. (2003) J. Neurol. 250(3): III11-14.
2, Sakamoto M et al. (2002) Exp. Neurol. 177(1): 88-94.
3, Jakes R et al. (1999) Neurosci. Lett. 269(1): 13-16.
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