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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ alpha-Synuclein , Monoclonal Antibody, purified

Product Name OptimAbᵀᴹ alpha - Synuclein , Monoclonal Antibody, purified
Clone: Syn303; Host: Mouse, Monoclonal Antibody
Size 50 µg/50 µL
Catalog # MMS-5085-050
US$ $190
Description

Alpha-Synuclein is a 140 amino acid protein that is implicated in Parkinson’s disease, Alzheimer’s disease, Lewy body dementia, and multiple system atrophy. It is mainly produced in the brain, but is also present at low levels in many other tissues. The protein contains 3 domains, a N-terminal amphipathic domain, a central hydrophobic domain which contains the NAC region (non-amyloid-beta component), involved in protein aggregation, and a C-terminal proline-rich domain. At least 3 isoforms of alpha-Synuclein are generated by alternative splicing, the most common form being the full length 1-140.

Host:Mouse
Clone: Syn303
Isotype: IgG1
Reactivity: Human, mouse and rat (by sequence identity)
Immunogen: This monoclonal antibody was raised against oxidized alpha-Synuclein
Concentration:1 mg/mL
Formulation:PBS (with no preservatives). The Ab is purified
Applications:The Ab is effective in immunoblotting (WB) and immunohistochemistry (IHC).

Detailed Information Datasheet
Storage 4°C
References Beach TG et al. (2008)Acta Neuropathol. 116(3): 277-288.
     
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