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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ alpha-Synuclein , Monoclonal Antibody, purified

Product Name OptimAbᵀᴹ alpha - Synuclein , Monoclonal Antibody, purified
Clone: 4B12; Host: Mouse, Monoclonal Antibody
Size 100 µg/100 µl
Catalog # SIG-39730-100
US$ $355

Alpha-Synuclein is a 140 amino acid protein that is implicated in Parkinson’s disease, Alzheimer’s disease, Lewy body dementia, and multiple system atrophy. It is mainly produced in the brain, but is also present at low levels in many other tissues. The protein contains 3 domains, a N-terminal amphipathic domain, a central hydrophobic domain which contains the NAC region (non-amyloid-beta component), involved in proetin aggregation, and a C-terminal proline-rich domain. At least 3 isoforms of alpha-Synuclein are generated by alternative splicing, the most common form being the full length 1-140.

Clone: 4B12
Isotype: IgG1
Reactivity: Human; does not react with Mouse or Rat alpha-Synuclein
Immunogen: The 4B12 Ab was raised against purified, E.coli produced human alpha-Synuclein. The epitope lies within aa 103-108 of alpha-Synuclein
Concentration:1 mg/mL
Formulation:PBS (with no preservatives). The Ab is purified
Applications:The Ab is effective in immunoblotting (WB), immunohistochemistry (IHC) and ELISA.
Working Dilutions:WB: 1/100 - 1/10.000 (predicted MW: 16 kDa)

Detailed Information Datasheet
Storage 4°C
References Yavich et al. (2005) Neurobiol. Dis. 20(2): 303-313.
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