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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ alpha-Synuclein , Monoclonal Antibody, purified

Product Name OptimAbᵀᴹ alpha - Synuclein , Monoclonal Antibody, purified
Clone: 4D6; Host: Mouse, Monoclonal Antibody
Size 100 µg/100 µl
Catalog # SIG-39720-100
US$ $355

Alpha-Synuclein is a 140 amino acid protein that is implicated in Parkinson’s disease, Alzheimer’s disease, Lewy body dementia, and multiple system atrophy. It is mainly produced in the brain, but is also present at low levels in many other tissues. The protein contains 3 domains, a N-terminal amphipathic domain, a central hydrophobic domain which contains the NAC region (non-amyloid-beta component), involved in proetin aggregation, and a C-terminal proline-rich domain. At least 3 isoforms of alpha-Synuclein are generated by alternative splicing, the most common form being the full length 1-140.
mAb 4D6 reacts with human, mouse and rat alpha-Synuclein. It does not react with beta-Synuclein or gamma-Synuclein.

Clone: 4D6
Isotype: IgG1
Reactivity: Human, Mouse, Rat
Immunogen: The 4D6 Ab was raised against puridied, E.coli produced human alpha-Synuclein
Concentration:1 mg/mL
Formulation:PBS (with no preservatives). The Ab is purified
Applications:The Ab is effective in immunoblotting (WB), immunohistochemistry (IHC) and ELISA.
Working Dilutions:WB: 1/500 - 1/1.000

Detailed Information Datasheet
Storage 4°C
References Golkovo M et al. (2005) Biochem. 44: 8251-8259.
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