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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ Prion , Monoclonal Antibody, purified

Product Name OptimAbᵀᴹ Prion , Monoclonal Antibody, purified
Clone: 6D11; Host: Mouse, Monoclonal Antibody
Size 100 µg/50 µL
Catalog # SIG-39810-100
US$ $355

Prion protein (PrP), also known as CD230, is mainly produced in the nervous sytem. PrP exists as different isoforms, among which the normal PrPc, and the 'scrapie' isoform PrPSc. PrPSc is misfolded and associated to multiple disorders including bovine spongiform encephalopathy, Gerstmann-Straüssler-Scheindker disease (GSS) and the Creutzfeldt-Jakob disease. It contains a much higher beta-sheet content than PrPc, and tends to form protease-resistant aggregates. A hypothesis to support the propoagation of these aggregates and their role in neurodegeneration is that the change from normal PrPc is due to its interaction with PrPSc (conformation conversion hypothesis). 6D11 reacts with both the PrPc and PrPsc forms. The epitope falls within amino acids 93-109 of PrP.

Clone: 6D11
Isotype: IgG2a,k
Reactivity: Human, Bovine, Sheep, Mule Deer, Elk, Mouse, Hamster
Concentration:2 mg/mL
Formulation:PBS (with no preservatives). The Ab was purified on Protein A
Applications:The Ab is effective in immunoblotting (WB), immunohistochemistry (IHC) and ELISA.
Working Dilutions:WB: 1/500
IHC: 1/500 - 1/1.000 (epitope must be unmasked by pretreatment with either 70% formic acid for 10-30min at RT, or hydrolytic autoclaving)
ELISA: 1/100- 1/10.000

Detailed Information Datasheet
Storage 4°C
References 1, Laurén J, et al. (2009) Nature 457(7233): 1128-1132.
2, Sigurdsson EM, et al. (2003) Neurosci. Lett. 336: 185-187.
3, Spinner DS et al. (2003) Curr. Med. Chem.- Immun. Endoc. & Metab. Agents 3: 119-135.
4, Adler V, et al. (2003) J. Mol. Biol. 332:47-57.
5, Kascsak RJ, et al. (1997) Immunol. Invest. 26(1-2): 259-268.
6, Kascsak et al. (1993). Dev. Biol. Stand. 80: 141-151.
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