Tau proteins belong to the microtubule-associated protein (MAP) family and are involved in the pathogenesis of Alzheimer’s disease. In the human brain, there are six Tau isoforms ranging from 352 to 441 amino acids in length. These isoforms vary at the carboxy-terminus according to the presence of either three repeat or four repeat domains (R1-R4), in addition to the presence or absence of one or two insert domains at the amino-terminus. The epitope was subsequently mapped to amino acids 185-195 of human 2N4R Tau (longest isoform).
Host:MouseClone: 77E9Isotype: IgG1,kReactivity: HumanImmunogen: This monoclonal antibody was raised against full-length human TauConcentration:1 mg/mLFormulation:PBS (with no preservatives). The Ab is purifiedApplications:The Ab is effective in immunoblotting (WB) and immunohistochemistry (IHC). Positive control tissue: human Alzheimer's brain.Working Dilutions:WB: 1/100 - 1/1.000 IHC: 1/1.000 - 1/2.000