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Antibodies  >  OptimAb Antibodies  >>  OptimAbᵀᴹ Myelin Basic Protein , Monoclonal Antibody, purified

Product Name OptimAbᵀᴹ Myelin Basic Protein , Monoclonal Antibody, purified
Clone: SMI 99; Host: Mouse, Monoclonal Antibody
Size 100 g/100 l
Catalog # SMI-99P-100
US$ $318
Description

Myelin basic protein (MBP) is involved in nerves myelination, and induces immune reactivity in multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the CNS.
SMI 99 reacts with the sequence Ala-Ser-Asp-Tyr-Lys-Ser in position 131-136 of human MBP. The antibody detects MBP from most mammalian species. Pig and chicken MBP do not react and guinea pig MBP has slight reactivity. SMI 99 does not react with the 14 kDa form of rat MBP. SMI 99 detects developing and adult myelin, developing oligodendrocytes and distinguishes oligodendrocytes from astrocytes, microglia, neurons and other cells in brain sections.

Host:Mouse
Clone: SMI 99
Isotype: IgG2b
Reactivity: Mammalian; Pig and chicken MBP do not react, guinea pig MBP has slight reactivity; SMI99 does not react with the 14 kDa form of rat MBP
Immunogen: nd
Concentration:1 mg/mL
Formulation:PBS + 0.01% sodium azide; The Ab is purified
Applications:The Ab is effective in immunoblotting (WB), ELISA, immunohistochemistry (IHC) and immunocytochemistry (ICC).
Working Dilutions:WB: 1/1.000
ICC: 1/1.000
IHC: 1/2.000 - 1/4.000
ELISA: 1/1.000

Detailed Information Datasheet
Storage 4C
References 1, Mendz GL et al. (1985) Biochem. J. 228: 61-68.
2, DeRosbo NK et al. (1984) Neurochem. Res. 9: 1359-1369.
3, Carnegie PR et al. (1983) J. Neuroimmunol. 5: 125-134.
4, Dowse CA et al. (1983) J. Neuroimmunol. 5: 135-144.
     
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