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Peptides  >  Cancer Research Peptides  >>  Human PD-L1 inhibitor III

Product Name Human PD - L1 inhibitor III
Size 1 mg
Catalog # AS-65583
US$ $155
Purity Peak Area by HPLC ≥95%
Description

Programed cell death protein 1 (PD-1) is a cell surface receptor. PD-1 and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism.
Human PD-L1 inhibitor III is a peptide-based molecule. It binds to human PD-1 and inhibits PD-1/PD-L1 binding. This peptide, hPDL-1 inhibitor III has anchor residues (underlined), TEKDYRHGNIRMKLAYDL that influence binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach toward cancer treatment.

PD-L1 Related Peptides
Human PD-L1 inhibitor I, Cat# AS-65581
Human PD-L1 inhibitor II, Cat# AS-65582
Human PD-L1 inhibitor IV, Cat# AS-65584
Human PD-L1 inhibitor V, Cat# AS-65585

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
References Bardhan K., et.al, Front Immunol 7(550), (2016); Li Q., et.al, Oncotarget 7(40), 64967-64976 (2016); D'Errico G., et.al, Clin Transl Med 6(1), 3-12 (2017)
Molecular Weight 2223.7
Sequence
(One-Letter Code)
TEKDYRHGNIRMKLAYDL
Sequence
(Three-Letter Code)
H - Thr - Glu - Lys - Asp - Tyr - Arg - His - Gly - Asn - Ile - Arg - Met - Lys - Leu - Ala - Tyr - Asp - Leu - OH
     
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