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Peptides  >  Cardiovascular Related Peptides  >>  Protease-Activated Receptor-1, PAR-1 Agonist, amide

Product Name Protease - Activated Receptor - 1, PAR - 1 Agonist, amide
Size 1 mg
Catalog # AS-62936
US$ $66
Purity % Peak Area By HPLC ≥ 95%

This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Vogel, SM. et al. Physiol. Genom. 4:137-145 (2000).
Molecular Weight 1216.4
(One-Letter Code)
(Three-Letter Code)
H - Thr - Phe - Leu - Leu - Arg - Asn - Pro - Asn - Asp - Lys - NH2
Product Citations Kouzaki, H. et al. (2013). Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells J. Resp. Cell. Mol. Biol49(5):741-750. doi: 10.1165/rcmb.2012-0304OC

Mosnier, L. O. (2012). Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood doi: http://dx.doi.org/10.1182/blood-2012-08-452169.

Wang, W. et al. (2009). Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. Int J Cancer126, 599. doi: 10.1002/ijc.24904.
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