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Peptides  >  Cardiovascular Related Peptides  >>  Protease-Activated Receptor-3, PAR-3 Agonist, amide

Product Name Protease - Activated Receptor - 3, PAR - 3 Agonist, amide
Size 1 mg
Catalog # AS-62938
US$ $66
Purity % Peak Area By HPLC ≥ 95%

This peptide is one of the four PAR sub-types, and is acted upon by thrombin; not trypsin. It is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. PARs have been studied for their roles in itch and, their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR4. Co-expression of PAR3 and PAR4 enhances thrombin action suggesting that PAR3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR4.

Storage -20°C
References 1, Tsujii, K. et al. J Pharmacol Sci. 108:385-388 (2008).
2, Leger, AJ. et al. Circ, 114:1070-1077 (2006).
Molecular Weight 576.6
(One-Letter Code)
(Three-Letter Code)
H - Ser - Phe - Asn - Gly - Gly - Pro - NH2
Product Citations Keiichi, I. et al. (2014). Protease activated receptor-1, but not -2, -3 and -4, is the player in the pathogenesis of atrial fibrosis; the experiment by neonatal rat atrial fibroblasts. IJC Heart & Vess 2:21-23. doi: 10.1016/j.ijchv.2013.11.005

Firth, AL. et al. (2009). Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am. J. Physiol. Heart. Circ. Physiol 296, L979. doi: 10.1152/ajplung.90412.2008.

Rauch, BH. et al. (2004). Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ. Res 94, 340. doi: 10.1161/01.RES.0000111805.09592.D8
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