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Assay Kits  >  ELISA Kits  >>  SensoLyte ® Anti-alpha-Synuclein (Human) ELISA Kit

Product Name SensoLyte ® Anti - alpha - Synuclein (Human) ELISA Kit
Size 1 kit
Catalog # AS-55550-H
US$ $520

This kit is optimized to detect human alpha-Synuclein (α-Synuclein) in cell and tissue lysate, and in human body fluids such as cerebrospinal fluid (CSF) and plasma. Wells are pre-coated with anti-α-Synuclein monoclonal antibodies, blocked, and stabilized for long-term storage. The amount of α-Synuclein is quantified using sandwich ELISA: rabbit polyclonal anti-α-Synuclein specific antibodies directly conjugated to horseradish peroxidase (HRP) are used to detect captured α-Synuclein.

One Step Convenient Format

o Pre-coated and pre-blocked 96-well strip plate
o Ready-to-use substrate solution and other assay components
o One step assay (samples and detection antibody are added simultaneously)
o 1 hour assay time at room temperature (excluding incubation time)
Minimal Sample Size
o Requires only 10-20 μl of cell and tissue lysate or body fluids
High Sensitivity
o Detects 5 pg/ml of α-Synuclein (calculated as three standard deviations from the blank)
Broad Dynamic Range
o 8-500 pg α-Synuclein/ml in the assayed sample

RELATED PRODUCTS: alpha-Synuclein Recombinant Proteins
Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage 4°C
Product Citations Oh SH, et al. (2017). The cleavage effect of mesenchymal stem cell and its derived matrix metalloproteinase-2 on extracellular α-synuclein aggregates in parkinsonian models. Stem cells translational medicine. 2017 6(3):949-61. doi:10.5966/sctm.2016-0111

Vivacqua G, et al. (2016). Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson's Disease. PLoS One. 11(3):e0151156. doi: 10.1371/journal.pone.0151156.

Prusiner, B. S. (2015). Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism pnas 112 doi: 10.1073/pnas.1514475112.

Woerman, A. L. (2015). Propagation of prions causing synucleinopathies in cultured cells. PNAS 112 doi: 10.1073/pnas.1513426112.

Al-Nimer, MS. et al. (2014). Saliva α-synuclein and a high extinction coefficient protein: A novel approach in assessment biomarkers of Parkinson's disease. North Am J Med Sci 6, 633. doi: 10.4103/1947-2714.147980.

Maia, LF. et al. (2013). Changes in amyloid-β and tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein. Sci Transl Med 5, 194re2.

Smith, LM. et al. (2012). α-Synuclein and anti-α-synuclein antibodies in Parkinson’s disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. PloS One 7, e52285.
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