The BRST-2 clone D6 recognizes a 15 kDa glycoprotein known as Gross Cystic Disease Fluid Protein-15 (GCDFP-15). The BRST-2 antigen is expressed by apocrine sweat glands, eccrine glands (variable), minor salivary glands, bronchial glands, metaplasmic epithelium of the breast, benign sweat gland tumors of the skin and the serous cells of the submandibular gland. Breast carcinomas (primary and metastatic lesions) with apocrine features express the BRST-2 antigen. This monoclonal Ab is used for the qualitative identification of GCDFP-15 in human biological samples using immunohistochemistry (IHC) methods. The clinical interpretation of any staining or its absence should be complemented by morphological studies and proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Host:Mouse Clone: D6 Isotype: IgG2a Reactivity: Human Immunogen: This antibody was generated against gross cystic disease fluid protein 15 (GCDFP-15) Concentration:Lot specific Formulation:PBS + BSA + 0.1% sodium azide; The Ab is purified Applications: For research use applications; this Ab is effective in immunohistochemistry (IHC).
1, Fan CY, et al. (2000) Am. J. Surg. Pathol. 24(4): 579-586. 2, Wick MR, et al. (1989) Human Path. 20(3): 281-287. 3, Haagensen CD. (1986) Disease of the breast. 3rd ed., 250-267. W. B. Saunders Co. Philadelphia, PA. 4, Mazoujian, G, et al. (1984) Am. J. Surg. Pathol. 8(1): 43-50. 5, Mazoujian G, et al. (1983) Am. J. Pathol. 110: 105-111.