Peptides  >  Corticotropin Related Peptides
Corticotropin-releasing factor (CRF), a 41 amino acid-peptide widely distributed in the brain mediates endocrine as well as autonomic and behavioral responses to stress. Its receptor subtypes, CRF-R1 and CRF-R2, are expressed in the brain. CRF is hypersecreted from hypothalamic as well as from extrahypothalamic neurons in depression, resulting in hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and elevations of cerebrospinal fluid concentrations of CRF. This increase in CRF neuronal activity is believed to mediate certain behavioral symptoms of depression involving sleep and appetite disturbances, reduced libido and psychomotor changes. The hyperactivity of CRF neuronal systems appears to be a state marker for depression because HPA axis hyperactivity normalizes following successful antidepressant treatment. The CRF system may play a significant role in the regulation of energy balance. CRF and CRF-related peptides, which elicit their effects through G-protein-coupled receptors known in mammals as CRF(1) receptor and CRF(2) receptor, are capable of strong anorectic and thermogenic effects. CRF, urocortin and urotensin I share amino acid sequences and they inhibit food intake in mammals.

Ref: Richard, D. et al. Eur. J. Pharmacol. 440, 89 (2002); Mitchell, A. Neurosci. Biobehav. Rev. 22, 635 (1998); Arborelius, L. et al. J. Endocrinol. 160, 1 (1999); Isogawa, K. et al. J. Psychopharmacol. 17, 409 (2003).
 Product Size Catalog # US$  
Biotin - Corticotropin Releasing Factor, Biotin - CRF, human, rat
0.5 mg AS-23976 $303
Corticotropin Releasing Factor, CRF, human, rat
1 mg AS-24254 $190
Corticotropin Releasing Factor, CRF, ovine
0.5 mg AS-22932 $159
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