Proteolipid protein (PLP) and its DM20 isoform are the major membrane proteins of CNS myelin. PLP/DM20 play important roles in the formation of the intraperiod line and in maintaining axonal integrity. They are also involved in the early stages of axon-oligodendrocyte interaction and wrapping of the axon. PLP plays a role in the Pelizaeus-Merzbacher disease (PMD), a myelin disorder of the CNS.
Ref: Yool, D. et al. J. Neurosci. Res. 63, 151 (2001); Woodward K. and S. Malcolm, Trends Genet 15, 125 (1999).