Peptides  >  Arg-Phe-Amide RFamide Related Peptides
FMRF-amide-related peptides (FaRPs) are small peptides of 418 amino acids with RFamide (arg-phe-NH2) at the C terminus. The first RFamide peptide was isolated in 1977 by Price and Greenberg as a cardioexcitatory peptide from the cerebral ganglia of Venus mussel; since then, other FaRPs have been described in the nervous systems of all major animal phyla, including vertebrates. Aside from the known function of regulating feeding, FMRF amide related peptides have been found to stimulate growth hormone release in amphibians; modulate central serotonergic transmission, the opioid systems and pain regulation in vertebrates; and produce antipsychotic-like effects when centrally administered in rodents.

Ref: Price, DA. and MJ. Greenberg, Science 197, 570 (1977); Schachtner, J. et al. J. Exp. Biol. 207, 2389 (2004); Anderson, L. et al. Exp. Biol. Med. 229, 291 (2004); Homberg, U. et al. Cell Tissue Res. 259, 401 (1990); Taghert, PH. Microsc. Res. Tech. 45, 80 (1999); Brody, T. Trends Genet. 15, 333 (1999); Perry, SJ. et al. FEBS Lett. 409, 426 (1997); Muthal, AV. et al. Neuropeptides 31,319 (1997); Lange, AB. and I. Ochard, Peptides 19, 459 (1998); Lee, K. et al. J. Biol. Chem. 279, 50781 (2004); Humphreys, M. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 286, 417 (2004); Grimmelikhuijzen CJ. and D. Graff, Peptides 63, 477 (1985); Dockray, GJ. et al. Nature (London) 293, 656 (1981).
 Product Size Catalog # US$  
26Rfa, Hypothalamic Peptide, human
1 mg AS-61651 $215
26Rfa, Hypothalamic Peptide, rat
1 mg AS-61650 $215
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